Endocrine Abstracts

We investigated the SNP rs16944 in German type 2 diabetes (T2D) patients and healthy controls (HC) and correlated the findings with concentrations of VD metabolites.Methods: 504 T2D patients and 447 HC were genotyped by a Taqman assay. Additionally 25(OH)D3 and 1,25(OH)2D3 plasma levels of 76 T2D patients and 267 HC were measured by radioimmunoassay.Results: The AA genotype was significantly less fr...

Type 2 diabetes (T2D) patients have a high cardiovascular risk due to vascular inflammation and dyslipidaemia. Furthermore vitamin D (VD) deficiency is highly prevalent. Our aim was to elucidate the role of fatty acid receptors in inflammatory pathways and their regulation by VD. We therefore examined the VD effect on gene expression of Arachidonate 5-lipoxygenase (ALOX-5) and Sphingosine-1-phospate receptors (S1PR1 and S1PR2) in primary isolated monocytes of T2D patients and ...

Introduction: Hypercholesterolemia is frequently found in patients with type 2 diabetes (T2D). Cholesterol is metabolized from 7-dehydrocholesterol by 7-dehydrocholesterol reductase (DHCR7) from 7-dehydrocholesterol, a precursor of pre-vitamin D3. Therefore single nucleotide polymorphisms (SNP) in the DHCR7 gene could regulate cholesterol levels and concentrations of vitamin D metabolites (25(OH)D3 or 1,25(OH)2D3). For this purpose we investiga...

Dysregulated T helper cells and vitamin D (VD) deficiency are important factors in the pathogenesis of Type 1 diabetes mellitus (T1D). Therefore, we investigated the immune effects of high dose VD-treatment on gene expression (GE) pattern in T helper cells (Th) before and after VD-therapy in patients with T1D.Methods: Seven T1D patients with 25(OH)D3 levels below 20 ng/ml received 3 months 4000 IU/d Vigantol oil. The 25(OH)D3 plasma...